The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study
Wu et al. now use two populations encompassing almost 1,500 subjects to demonstrate that the gut microbiota is altered in prediabetes and diabetes independent of diabetes medication.
Cell Metabolism, 32 (3), 379-390. e3
An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans
We show that the diet improves liver fat metabolism, promotes rapid shifts in the gut microbiota, increases circulating folate, and upregulates expression of genes involved in folate-dependent one carbon metabolism in the liver.
Cell Metabolism 27 (3), 559-571. e5
Microbially produced imidazole propionate impairs insulin signaling through mTORC1
Ara Koh et al identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher concentrations in subjects with versus without type 2 diabetes.
Cell 175 (4), 947-961. e17
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Our findings provide support for the notion that altered gut microbiota mediates some of metformin's antidiabetic effects.
Nature Medicine 23 (7), 850
Linking microbiota to human diseases: a systems biology perspective
We discuss how systems biology approaches combined with new experimental technologies may disentangle some of the mechanistic details in the complex interactions of diet, microbiota, and host metabolism.
Trends Endocrinol. Metab. 26 (12), 758-770
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