Metagenomics

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Metagenomics

Preview: Fishing for obesity-related gut microbiome enterotype

With tripled meat but sharply reduced grain consumptions over the past 30 years in China, it is not unexpected that the diet-gut microbiota interactions are increasingly playing a significant role in contributing to the rising obesity in this country. National programs advocating for precise nutritional interventions targeting both the host and gut microbes are essential.

Cell Host & Microbe2024

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Navigating the B vitamins: Dietary diversity, microbial synthesis, and human health

Here, we delve into the impact of these factors on B vitamins and introduce strategies,with a focus on microbiota-based therapeutic options, to enhance their availability for improved well-being.

Cell Host & Microbe2024

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Spotlight: Unveiling Strain-Level Dynamics in Probiotic Activity

Divergent gene content among distinct probiotic strains contributes to varied or conflicting clinical efficacies.

Trends in Microbiology2023

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Human Gut Microbiome Researches Over the Last Decade: Current Challenges and Future Directions

Eight selected challenges we are facing in human gut microbiome researches.

Phenomics2023

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Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin

Improvement of hepatic lipid metabolism by silymarin largely depends on gut microbes and their B12 producing ability.

Nature Communications 14, 4772023

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The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study

Wu et al. now use two populations encompassing almost 1,500 subjects to demonstrate that the gut microbiota is altered in prediabetes and diabetes independent of diabetes medication.

Cell Metabolism, 32 (3), 379-390. e32020

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An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans

We show that the diet improves liver fat metabolism, promotes rapid shifts in the gut microbiota, increases circulating folate, and upregulates expression of genes involved in folate-dependent one carbon metabolism in the liver.

Cell Metabolism 27 (3), 559-571. e52018

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Microbially produced imidazole propionate impairs insulin signaling through mTORC1

Ara Koh et al identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher concentrations in subjects with versus without type 2 diabetes.

Cell 175 (4), 947-961. e172018

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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

Our findings provide support for the notion that altered gut microbiota mediates some of metformin's antidiabetic effects.

Nature Medicine 23 (7), 8502017

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