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Topic
Metabolomics
Metabolomics
Human Gut Microbiome Researches Over the Last Decade: Current Challenges and Future Directions
Eight selected challenges we are facing in human gut microbiome researches.
Phenomics
2023
VIEW
Microbial metabolites in chronic heart failure and its common comorbidities
This study aimed to identify microbial signatures that contribute to the shared etiologies between chronic heart failure (CHF), type 2 diabetes, and chronic kidney disease.
EMBO molecular medicine
2023
VIEW
An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans
We show that the diet improves liver fat metabolism, promotes rapid shifts in the gut microbiota, increases circulating folate, and upregulates expression of genes involved in folate-dependent one carbon metabolism in the liver.
Cell Metabolism 27 (3), 559-571. e5
2018
VIEW
Microbially produced imidazole propionate impairs insulin signaling through mTORC1
Ara Koh et al identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher concentrations in subjects with versus without type 2 diabetes.
Cell 175 (4), 947-961. e17
2018
VIEW
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Our findings provide support for the notion that altered gut microbiota mediates some of metformin's antidiabetic effects.
Nature Medicine 23 (7), 850
2017
VIEW
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Topic
T2D
NAFLD
Metagenomics
Metabolomics
Metabolic diseases
Medication
Exercise
Heart failure
Diet
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