During my undergraduate study, I have a great interest in the interactions between human microbes (especially gut microbes) and diseases. Based on College Students' Innovative Training Project, I received some scientific research training. We used 16S rRNA amplicon and shallow metagenomic sequencing (SMS) strategies to uncover the gut microbiota of patients with adenoma, colorectal cancer, and hemorrhoid. We found that some of the dominant species, such as Prevotella copri, Bacteroides dorei, and Bacteroides vulgatus, could be responsible for causing colorectal diseases. Also, the SMS data uncovered diverse antibiotic resistance genes of tetracycline, macrolide, and beta-lactam, which could be a result of antibiotic overuse.
In my graduation project, I collected 42 skin microbial samples, 19 samples of acne teenagers (Group E) and 23 samples of healthy teenagers (Group H). α diversity in group E was lower than that in group H. The abundance of Proteobacteria and Bacteroidetes in group E was significantly lower than that in group H, while the abundance of Actinobacteria was higher than that in group H. The sum of abundance of Propionibacterium and Staphylococcus was significantly increased in group E (P < 0.05). Through culture isolation and whole genome sequencing, some Staphylococcus epidermidis strains that may be associated with acne-causing were found.
In the future, I hope to do some in-depth researches to clarify the roles that gut microbes play within human disease, to explain the genetic and molecular basis. I am currently studying bioinformatics and learning computational programming using python and R, preparing for my graduate work in advance.
Previous publications:
1.Yang Y, Li X, Yang Y, Shoaie S, Zhang C, Ji B and Wei Y (2021) Advances in the Relationships Between Cow’s Milk Protein Allergy and Gut Microbiota in Infants. Front. Microbiol. 12:716667.（IF：6.064）
2.Liu Y, Li X, Yang Y, Liu Y, Wang S, Ji B and Wei Y (2021) Exploring Gut Microbiota in Patients with Colorectal Disease Based on 16S rRNA Gene Amplicon and Shallow Metagenomic Sequencing. Front. Mol. Biosci. 8:703638.（IF：6.113）
3.Yang Y,Wei Y #et al. (2022) Advances in the human skin microbiota and its roles in cutaneous diseases. Microbial Cell Factories（under review）