Gut microbiota has been found to interact with diet and drugs, influencing the development and treatment of metabolic diseases. However, the underlying mechanisms are not fully understood. In my study, I am using an in vitro gut simulator called the Simulated Human Intestinal Redox Model (SHIRM) to cultivate human gut microbiota from fecal samples. By analyzing changes in composition, function, and diversity of the microbiota in response to diet and drugs, I aim to better understand the host-microbes-diet/drugs interactions. Integrating culturomics, genomics, and metabolomics, my research seeks to elucidate the relationship between gut microbiota and human diseases.
Through the use of SHIRM, I am investigating how human gut microbiota interacts with diet and drugs. This interdisciplinary approach combines culturomics, genomics, and metabolomics to comprehensively analyze the dynamic changes in gut microbiota composition, function, and diversity. By unraveling the complex connections between the host, gut microbiota, and environmental factors, my research aims to establish the causal links between gut microbiota and human diseases, providing valuable insights into the intricate interplay of host-microbes-diet/drugs interactions.