Bacteriophages, not only as a potentially effective substitute for chemical antibiotics but also in regard to their influence on eukaryotic cells and the reconfiguration of the intestinal microbiome, have been the primary areas of research interest for me over the past decade. I have established the local customized pipeline for metagenomics analysis of gut phageome (Shahin, K., et al., Gut Pathog 15, 39. 2023). Additionally, I examined the effects of prolonged phage utilization on the composition of the gut microbiota, metabolites, and the signaling pathways of epithelial cells. By utilizing the ability of phages to selectively target bacterial host cells, my objective is to underscore the potential of phages in the prevention of cardiometabolic diseases that are linked to the gastrointestinal microbiome.
Shahin K, Soleimani-Delfan A, He Z, Sansonetti P, Collard JM. Metagenomics revealed a correlation of gut phageome with autism spectrum disorder. Gut Pathog. 2023 4:39. PMID: 37542330; PMCID: PMC10403902
Shahin K, Bao H, Zhu S, Soleimani-Delfan A, He T, Mansoorianfar M, Wang R. Bio-Control of O157:H7, and Colistin-Resistant MCR-1-Positive Escherichia Coli Using a New Designed Broad Host Range Phage Cocktail. LWT- Food Science and Technology 2022 154; 112836. https://doi.org/10.1016/j.lwt.2021.112836
Zhang L, Ma C, Liu J, Shahin K, Hou X, Sun L, Wang H, Wang R. Antiviral effect of a bacteriophage on murine norovirus replication via modulation of the innate immune response. Virus Res. 2021 305:198572. PMID: 34555440.
Shahin K, Barazandeh M, Zhang L, Hedayatkhah A, He T, Bao H, Mansoorianfar M, Pang M, Wang H, Wei R, Wang R. Biodiversity of New Lytic Bacteriophages Infecting Shigella spp. in Freshwater Environment. Front Microbiol. 2021 17:619323. PMID: 33679642; PMCID: PMC7925395
Shahin K, Bouzari M, Komijani M, Wang R. A New Phage Cocktail Against Multidrug, ESBL-Producer Isolates of Shigella sonnei and Shigella flexneri with Highly Efficient Bacteriolytic Activity. Microb Drug Resist. 2020 26:831-841. PMID: 32031907